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Former police detective Adrian Monk (Tony Shalhoub), whose photographic memory and amazing ability to piece together tiny clues made him a local legend, has suffered from intensified obsessive-compulsive disorder and a variety of phobias since the unsolved murder of his wife, Trudy, in 1997. Now on psychiatric leave from the San Francisco Police Department and working as a freelance detective/ consultant on difficult cases, Monk hopes to convince his former boss, Captain Leland Stottlemeyer (Ted Levine), to allow him to return to the force. Stottlemeyer, who wavered between admiration for Monk and annoyance at his eccentricities during the first season, is becoming more of a friend to Monk as the series develops, frequently calling him in to help, as much for Monk's benefit as for his own. However, he knows Monk's limitations as well as his strengths and may still harbor doubts about the wisdom of allowing Monk to carry a gun or subdue a perpetrator. Stottlemeyer's second-in-command, Lieutenant Randall Disher (Jason Gray-Stanford), also seems to be developing both admiration and compassion for the man he once labeled "the defective detective."
Despite flaws and inadequacies all around, the three are becoming an increasingly effective team, with additional help from Monk's personal assistant. From the double-episode pilot through the first half of season three, Monk was aided by his nurse, Sharona Fleming (Bitty Schram). But in the tenth episode of the third season, Sharona was replaced by a new assistant, Natalie Teeger (Traylor Howard). Like Sharona, a divorcee with a son named Benjy, Natalie is a single parent, a widow with a daughter named Julie (Emmy Clarke). Unlike Sharona, Natalie is not a nurse but a former bartender with a fresh perspective on "Mr. Monk," as she still addresses her new boss.
理查德·麦登,达斯汀·霍夫曼,圭多·卡普里诺,乔治·卡普托,斯图尔特·马丁,安娜贝尔·斯考莉,塔蒂亚娜·伊内兹·纳尔多,莎拉·菲尔伯鲍姆
Alessandro Gassman,Carolina Crescentini,Tosca D'Aquino,Antonio Folletto,Massimiliano Gallo,Gianfelice Imparato,Gennaro Silvestro,Simona Tabasco,Giovanni Esposito,Serena Iansiti,Gioia Spaziani,Marika Costabile,Alessia Lamoglia,Irina Munteanu,Miria
玛雅·厄斯金,安娜·康克尔,梅洛拉·沃尔特斯,泰勒·尼科斯,安娜·尼奥斯基,布拉迪·艾伦,托尼·埃斯皮诺萨,乔纳斯·贝尔斯,吉尔·巴塞,黛安娜·德拉诺,布兰登基纳,蒂姆·罗斯,美恵子·希尔曼,杰西·霍奇斯,诺亚·米尔斯,斯泰西·奥西-库福尔,凯利·勒夫科维茨,Mutsuko Erskine,Dylan Gage,Taj Cross,Ceanna Kilpatrick,Sami Rappoport,Dallas Liu,Ivan Mallon,Hannah Mae,大卫·鲍,理查德·卡恩,艾伯特·豪威尔
玛丽娜·汉斯,Minette,马修·德米,泽莉·里克森,Jérémy Gillet,Luca Terracciano,范林丹,凯瑟琳·蒙切特,Marie Bouvet,伊夫·雅克,Fadily Camara,安德里亚·龙卡多,道恩·福特,朱莉娅·福雷,让-查理·克里切特,Anne-Charlotte Pontabry,Théo Augier,Oudesh Rughooputh,哈基姆·杰米利,Poppée Bashung,弗兰克·布鲁诺,赛勒斯·萨赫迪,Rodolphe Couthouis,斯特凡·冯金诺
朱莉娅·奥蒙德,梅晨·阿米克,瑞秋·波士顿,珍娜·迪万,丹尼尔·迪托马索,艾里克·温特
布莱德利·库珀,保罗·路德,伊丽莎白·班克斯,艾米·波勒,克里斯托弗·米洛尼,詹妮安·加罗法洛,玛格丽特·莫罗,乔·洛·特鲁格里奥,肯·马里诺,戴维·海德·皮尔斯,莫莉·香侬,凯文·苏斯曼,贾达·弗雷德兰德,詹克·欧思,迈克尔·伊恩·布莱克,迈克尔·肖沃特,A·D·迈尔斯,H·乔恩·本杰明,玛丽萨·瑞安,乔西·查尔斯,约翰·斯拉特里,麦可拉·沃金丝,兰道尔·朴,杰玛·梅斯,蕾克·贝尔